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AM Only Antioxidant Defense Serum
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Antioxidant Defense Serum
Antioxidant Defense Serum
Antioxidant Defense Serum
Antioxidant Defense Serum
Antioxidant Defense Serum
Dr. Carl Truesdale, MD
Dr. Carl Truesdale, MD
Double Board-Certified Facial Plastic Surgeon · Beverly Hills
Formulated by Founder
Step 2 · Antioxidant Defense · Morning

Antioxidant Defense Serum

Dual-form Vitamin C, niacinamide, ferulic acid, CoQ10 · 30 mL / 1 fl oz
★★★★★ 4.5 · 4 verified reviews

Your daily Vitamin C, ferulic acid, and radiance shield. Dual-form Vitamin C, niacinamide, ferulic acid, and CoQ10 protect against environmental aging and brighten tone — the morning step that sets everything else up.

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Tested on all skin tones
Including melanin-rich types
4.5 ★★★★★
4 verified reviews
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Set your expectations

What to expect, and when

Real skin change follows your skin’s own renewal cycle. Here is the honest timeline.

Weeks 1–2
Skin feels more hydrated, calm and comfortable. Surface texture starts to smooth.
Weeks 3–4
Tone looks brighter and more even; makeup sits better.
Weeks 8–12
Firmness and fine lines improve. This is the point worth judging results on.

Individual results vary. Backed by our 30-day money-back guarantee on your first order. Try it. Not right? Send it back within 30 days of delivery.

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Active Ingredients

The science inside Antioxidant Defense Serum.

Click any ingredient to see exactly how it works and why Dr. Truesdale chose it.

Tetrahexyldecyl Ascorbate (Oil-Soluble Vit C)
AM Only · Deep brightening
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Most stable, penetrating form of Vitamin C
Unlike standard L-ascorbic acid, THDA doesn't oxidize, works without low pH, and penetrates the lipid layer to work where brightening and collagen synthesis actually happen. Ideal for melanin-rich skin.
BrighteningStable Vitamin CDeep penetrationMelanin-safe
Sodium Ascorbyl Phosphate (Water-Soluble Vit C)
AM Only · Surface brightening
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Second form of Vitamin C — surface brightening and protection
While THDA works deep, SAP brightens at the skin surface. Together the dual-form Vitamin C delivers brightening at both levels — far more complete than single-form serums.
Surface brighteningStableTwo-level approach
Niacinamide 4%
AM Only · Tone + barrier
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One of the most well-researched actives in skincare
At the evidence-backed 4% concentration, niacinamide inhibits melanin transfer, reduces redness, minimizes pores, and strengthens barrier. Particularly valuable for melanin-rich skin.
Pore minimizingRedness reductionHyperpigmentationBarrier support
Ferulic Acid
AM Only · Antioxidant amplifier
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Doubles the photoprotection of Vitamin C
The vitamin C + E + ferulic pairing is the most-proven antioxidant combination in skincare. Artisa includes it for exactly that reason — it stabilizes Vitamin C and doubles its UV protection efficacy throughout the day.
AntioxidantVitamin C amplifierUV defense
How To Use

Your routine

☀ Morning

Apply 3–5 drops to clean, dry skin every morning. Gently press into skin. Allow to absorb for 60 seconds before applying Renewal Repair Cream and SPF. Vitamin C + SPF together outperform either alone.

🌙 Evening

Not applicable — this is a morning-only serum. In the evening, use Radiance Cleanser → Age Reversal Cream → Renewal Repair Cream.

Quick answers
Yes — specifically designed for it. Every formula is tested across all skin tones in Dr. Truesdale's Beverly Hills practice.
Your first Artisa order. Give it a real try. If it isn't right for you, email contact@artisaskincare.com within 30 days of delivery with your order number, how long you used it, and what you didn't like. We'll send return instructions. Send the products back (opened is fine) with tracking. Your refund is processed after we receive your return. Return shipping is your responsibility. One per customer, U.S. orders only. Subscription renewals and repeat orders are final once shipped. We email you before every renewal so you can skip or cancel first. If your skin reacts to a product on any order, email us with a photo and we'll make it right.
Yes. Antioxidant Defense Serum is AM-only and pairs perfectly with Age Reversal Cream (PM retinol). The Masterpiece Collection is built around exactly this layering.
Complete Your Routine

Also from Artisa

Build a complete routine with the Masterpiece or Brightening Collection for the best results.